INVESTIGATION OF L. MONOCYTOGENES – HEP-2 CELLS RELATIONSHIPS BY CULTURE BASED AND MICROSCOPY TOOLS

Published in Scientific Papers. Series D. Animal Science., Vol. LVI
Written by Marius Eduard CAPLAN, Lorena Andreea MATEESCU

The first step of the infection process must triggered by virulent Listeria monocytogenes strains is the attachment to, and invasion of, the gastrointestinal epithelium. The purpose of this paper was to investigate the ability of L. monocytognes species isolated from different clinical specimens to adhere, invade and multiply in HEp-2 cells. All investigated L. monocytogenes strains exhibited the ability to adhere, invade and multiply in the eukaryotic HEp-2 cells, the internalization being followed by the activation of cellular signaling pathways, leading to the release of thin, long cytoplasmic extensions, vacuolization and apoptosis. The ability of L. monocytogenes strains to survive inside the host cell could explain their implication in chronic recurrent diseases and long-term colonization, the internalization process providing effective protectionagainst host defenses and antibiotic treatment.

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CAPLAN M. E., MATEESCU L. A. 2013 INVESTIGATION OF L. MONOCYTOGENES – HEP-2 CELLS RELATIONSHIPS BY CULTURE BASED AND MICROSCOPY TOOLS. Scientific Papers. Series D. Animal Science., Vol. LVI, ISSN 2285-5750, 86-89.


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