ISSN 2285-5750, ISSN CD-ROM 2285-5769, ISSN-L 2285-5750, ISSN Online: 2393 – 2260
 

EXPERIMENTAL STUDY OF CARDIOVASCULAR RECEPTORS BEHAVIOR IN RAT HEART AND AORTA. THE IMPACT OF SERUM FACTORS FROM HYPERTENSIVE SUBJECTS

Published in Scientific Papers. Series D. Animal Science, Vol. LXIII, Issue 2
Written by Cristian Romeo REVNIC, Flory REVNIC, Silviu VOINEA

Hypertension or elevated arterial blood pressure is the most common risk factor for cardiovascular disease and death and by the year 2025 the number of people with arterial hypertension will reach 1.5 billion. Objectives are to get some insights concerning the mechanisms of induction of arterial hypertension (AHT). We used freshly collected fragments of rat heart and aorta incubated with serum from hypertensive (HT) subjects as well as with different Na2HPO4 concentrations in order to follow up the changes in 45CaCl2 fluxes, in 3H Serotonine, 3H Noradrenaline (NA) as well as in 3H Cortisol uptake in rat aorta and heart. Our data have pointed out significant changes in 45CaCl2 uptake in rat aorta and heart incubated with serum from (HT) subjects which can be pathologically correlated with the mechanism of (AHT) induction. A significant decrease in 3H Serotonine and 3H NA has been recorded both in rat aorta and heart incubated with (HT) serum which can be accounted for a suppressing of normal inhibitory mechanism. As far as 3H Cortisol uptake is concerned, no change was noticed in the case of incubation with sera from (HT) subjects both in heart and aorta. When different Na2HPO4 have been used, 3H NA and 3H Serotonine uptake in rat aorta have pointed out an increase in 3H NA uptake at phosphate concentrations close to the physiology ones, while in the case of 3H Serotonine, there is a proportional increase in its uptake at higher Na2HPO4 concentrations. It seems that 45CaCl2 admission depends very much on organic Na2HPO4 concentration.

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© 2019 SCIENTIFIC PAPERS. SERIES D. ANIMAL SCIENCE. To be cited: SCIENTIFIC PAPERS. SERIES D. ANIMAL SCIENCE.

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