Published in Scientific Papers. Series D. Animal Science, Vol. LXV, Issue 2
Written by Alexander OSTACHUK, Lilia OSHKINA, Alexei ZAGUMENNOV, Irina GORYACHEVA, Daria ZERNOVA, Lyubov MELNIKOVA
The article investigates the effect of an organoselenium compound on the antioxidant status of the body of laboratory animals when they are administered a cadmium compound. Cadmium compounds are widely known eco-pollutants, the toxic effect of which is due to their ability to stimulate free radical processes in the body of animals and humans. The purpose of this work was to identify aspects of cadmium toxicity due to its thiol specificity and features of the short-term adaptation of the antioxidant system to the administration of a toxicant in rats at the stages of ontogenesis. At the same time, the effectiveness of the organic selenium-containing compound was evaluated. In the tissues, the accumulation of lipid peroxidation products, as well as the content of selenium in the blood plasma, liver, and testicles of animals, were evaluated. In the course of the research, it was found that the prophylactic administration of selenopyran to experimental animals reduced the manifestation of toxicosis caused by cadmium. A similar effect of the drug is due to a decrease in the degree of damage to cell membranes and intracellular structures by free radical oxidation products.
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