Published in Scientific Papers. Series D. Animal Science, Vol. LXV, Issue 2
Written by Diana MOISA (DANILOV), Lorena DEDIU, Valentina COATU, Nicoleta DAMIR
Pharmaceutically active compounds (PhACs) occurred in aquatic environments and have the potential to adversely affect the homeostasis of the endocrine axis leading to immunological, developmental, neurological and reproductive disarray at the organism level. These compounds are frequently discharged or run-off into the water stream and consequently is an increasing concern in research for the threat posed by PhACs on aquatic fauna. Fishes are vulnerable to different compounds, but the effects depend on specie, toxic concentration and exposure time. The concentrations of PhACs detected in the aquatic environment are relatively low but depending on the compound, they can reach up to a few hundreds of ng/g. The detection of pharmaceuticals in the aquatic environment has predominantly been reported in the developed world (USA, EU, Japan, and Australia) which are dominant countries in global pharmaceutical sales, but their presence tends to become ubiquitous. The aim of this paper is to highlight the main adverse effects of most common PhACs found in Danube river on fish health in order to assess the PhAC with the higher risk for fishes.
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