Published in Scientific Papers. Series D. Animal Science, Vol. LXIII, Issue 2
Written by Cristian Romeo REVNIC, Flory REVNIC, Silviu VOINEA

Hypertension or elevated arterial blood pressure is the most common risk factor for cardiovascular disease and death and by the year 2025 the number of people with arterial hypertension will reach 1.5 billion. Objectives are to get some insights concerning the mechanisms of induction of arterial hypertension (AHT). We used freshly collected fragments of rat heart and aorta incubated with serum from hypertensive (HT) subjects as well as with different Na₂HPO₄ concentrations in order to follow up the changes in ⁴⁵CaCl₂ fluxes, in ³H Serotonine, ³H Noradrenaline (NA) as well as in ³H Cortisol uptake in rat aorta and heart. Our data have pointed out significant changes in ⁴⁵CaCl₂ uptake in rat aorta and heart incubated with serum from (HT) subjects which can be pathologically correlated with the mechanism of (AHT) induction. A significant decrease in ³H Serotonine and ³H NA has been recorded both in rat aorta and heart incubated with (HT) serum which can be accounted for a suppressing of normal inhibitory mechanism. As far as ³H Cortisol uptake is concerned, no change was noticed in the case of incubation with sera from (HT) subjects both in heart and aorta. When different Na₂HPO₄ have been used, ³H NA and ³H Serotonine uptake in rat aorta have pointed out an increase in ³H NA uptake at phosphate concentrations close to the physiology ones, while in the case of 3H Serotonine, there is a proportional increase in its uptake at higher Na₂HPO₄ concentrations. It seems that ⁴⁵CaCl₂ admission depends very much on organic Na₂HPO₄ concentration.

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